Im now free of it all. They used DNA mapping and have screwed with one gene that actually controls the chromophore and makes it go malignant.
Did you have your case analyzed by Watson (the IBM supercomputer)?
Charlie Rose: To be on top of everything that's out there, all the trials that have taken place around the world, it seems like an incredible task--
Ned Sharpless: Well, yeah, it's r--
Charlie Rose: --for any one university, only one facility to do.
Ned Sharpless: Yeah, it's essentially undoable. And understand we have, sort of, 8,000 new research papers published every day. You know, no one has time to read 8,000 papers a day. So we found that we were deciding on therapy based on information that was always, in some cases, 12, 24 months out-of-date.
However, it's a task that's elementary for Watson.
Ned Sharpless: They taught Watson to read medical literature essentially in about a week.
Charlie Rose: Yeah.
Ned Sharpless: It was not very hard and then Watson read 25 million papers in about another week. And then, it also scanned the web for clinical trials open at other centers. And all of the sudden, we had this complete list that was, sort of, everything one needed to know.
Charlie Rose: Did this blow your mind?
Ned Sharpless: Oh, totally blew my mind.
Watson was proving itself to be a quick study. But, Dr. Sharpless needed further validation. He wanted to see if Watson could find the same genetic mutations that his team identified when they make treatment recommendations for cancer patients.
Ned Sharpless: We did an analysis of 1,000 patients, where the humans meeting in the Molecular Tumor Board-- doing the best that they could do, had made recommendations. So not at all a hypothetical exercise. These are real-world patients where we really conveyed information that could guide care. In 99 percent of those cases, Watson found the same the humans recommended. That was encouraging.
Charlie Rose: Did it encourage your confidence in Watson?
Ned Sharpless: Yeah, it was-- it was nice to see that-- well, it was also-- it encouraged my confidence in the humans, you know. Yeah. You know--
Charlie Rose: Yeah.
Ned Sharpless: But, the probably more exciting part about it is in 30 percent of patients Watson found something new. And so that's 300-plus people where Watson identified a treatment that a well-meaning, hard-working group of physicians hadn't found.
Charlie Rose: Because?
Ned Sharpless: The trial had opened two weeks earlier, a paper had come out in some journal no one had seen -- you know, a new therapy had become approved--
Charlie Rose: 30 percent though?
Ned Sharpless: We were very-- that part was disconcerting. Because I thought it was gonna be 5 perc--
Charlie Rose: Disconcerting that the Watson found--
Ned Sharpless: Yeah.
Charlie Rose: --30 percent?
Ned Sharpless: Yeah. These were real, you know, things that, by our own definition, we would've considered actionable had we known about it at the time of the diagnosis.
I don’t know why I always felt a member of the family deserved a people name.
Family dogs have been Joe and Jack.
Interested to see what moniker sticks on former Chunk.
Tired of just lyin around watching the tube. I dont feel like reading nd cant get up the initiative to draw.
I feel the same. All my pets have had regular names
"Curly" is coming up for the Komondoor followed by "Shemp" and "Marley".