@memester,
memester;116211 wrote: the chemical relationship between ammonia and pH is not specific to human biology.
No, but my particular expertise is rather specific to human biology and that of human pathogens; and while the routine chemistry of ammonia is high school level stuff, the relationship of ammonia to human disease is a completely different topic than its environmental toxicity to fish. Yes, we have many biological similarities to fish, but that is a generic statement, and fundamentally fish handle temperature, pH, and ion homeostasis completely differently than mammals.
The range of pH and temperatures compatible with life are extremely narrow compared with what is in that fishdoc table. I do not know much about ammonia toxicology, i.e. human disease from ammonia exposure. That's a rather subspecialized thing; I know a little bit about ammonia ingestion, but I emphasize the 'little' -- even ER physicians call Poison Control about that one.
There are a handful of
common scenarios we deal with in human medicine. The one of most interest to me, being an infectious disease specialist, is urease production by bacteria (H. pylori and Proteus mirabilis are the famous ones). These bacteria split urea into ammonia, which alkalinizes their environment by soaking up protons. This is a survival strategy for these bugs to live in acidic milieuxs. A urinary tract infection with Proteus usually results in a urine pH of 7 or 8, which is quite high compared with normal urine or urine infected with other bugs. It also makes Proteus prone to forming certain kinds of stones, which deposit under alkaline conditions.
We also commonly deal with
urea elevation. Urea is H3N-CO-NH3, a simple molecule that the liver synthesizes out of free ammonia in order to detoxify it. Ammonia mainly comes from deamination of amino acids from protein breakdown, whether from endogenous protein, the diet, or from gut flora. Patients with kidney failure can develop enormous elevations of urea (usually referred to as BUN or blood urea nitrogen), which has certain symptoms (mainly encephalopathy). Patients with kidney failure may also be very acidemic, but again the range of pH is extremely narrow compared with the environmental conditions in that article (we have a lot of buffering capacity in our blood), and I've
never heard a nephrologist talk about the implications of pH on urea chemistry or pathobiology. It may be real, but it's probably not clinically important.
Next, patients with advanced liver disease (i.e. cirrhosis) cannot make urea, so they accumulate pure ammonia, NH3. This also causes an encephalopathy, but it's generally felt that serum levels of NH3 are a proxy marker for other toxic things that accumulate.
We do not measure NH4+ ions under normal clinical circumstances. There are genetic disorders of amino acid metabolism, famously urea cycle disorders, and geneticists order all sorts of highly subspecialized tests to find out which enzyme is deficient or defective.
This isn't to display my feathers -- it's just to show that what I know about, what I teach about, and what I need to know to be a good doctor is quite a bit different than the conversation we're having.
memester;116211 wrote:neither one of you knows anything, but intend to tell us what these wonderful Climate Change people are up to; wonderful science - only it's not.
I've told you I know nothing -- I'm a dilettante at the climate change question.
Wonderful science? Well, you've run for the hills when I gave you a scientific global warming article to critique. You didn't even bother. That article may well be wonderful science, it may not, but if you won't even ATTEMPT to read it critically,
then I can't take seriously the judgments you pass on the whole domain of climate science.
memester;116211 wrote:You'll need to have more knowledge of what you speak about, in order to make such sly commentaries about people - and not expect to get something back, Paul.
Yeah, that was dickish of me. Sorry.
memester;116211 wrote:No use claiming it's not your field after you talk like that. You said the page was correct, thereby demonstrating your lack of skills.
It
was correct. At least the ammonia chemistry part was. The temperature and pH references were specifically to fish toxicology and not to ammonia chemistry. How many times would you like me to repeat that?
memester;116211 wrote:How can you look into climate science - as it's not your field either ?
I'm willing to critically evaluate ANY scientific article you put in front of me, including the one I linked. I've done plenty of journal clubs in my life. Scientific methodology is fairly uniform down to a point. I can't do advanced math, so complex modeling papers are harder for me to critique, but in general the climate change articles are fairly accessible to anyone with a science background.
memester;116211 wrote:I'd be terrified to be doctored by anyone with those skills. You might alter my blood chemistry and kill me. Then tell the family that it was not your particular field of medicine.
Yup. Live in fear. Of course, it so happens that today I saw a guy in acute renal failure with a BUN of 140, which is the highest I've ever seen, and I was giving him a bicarbonate infusion because of a severe metabolic acidosis. It saved his life. He'll still probably need dialysis, but that was true before I ever saw him. Wasn't my best case of the day, but it was a challenging one.
memester;116211 wrote:I think we are all decent people here.
We are. We spar and posture too much and talk too little. It's unproductive. I thank you for reminding us of this, it's important.