None in the last fifty years. I would say that individual research has lead to some advances in the medical field (such as the Polio vaccine and the recent cure for Ulcers) but the majority of 'breakthrough' or startlingly new drugs have been produced by Big Pharma.
This doesn't mean, however, that there is no incentive to invest in pharma research besides money. For example, I invest in cancer research every year, without a hope of ever recieving a penny in return - but then again, the money I give will help end cancer for people like my Father who had it twice, and it will help protect my children from cancer in the future.
There is a great amount of non-monetary return to be had in the investment of monies into drug research; if we weren't so focused on 'profit' we would either have curtailed many of the diseases and problems that plague mankind, or be farther along the path to doing so.
On Edit: Actually, I decided to do some research on non-profit Pharmas out there (I figured there must be some) and found the following that you might want to look at:
http://www.oneworldhealth.org/
They are attempting to do exactly what I was talking about: further the health of humanity as a whole without relying on the corporate profit model to do so. They are working on a cure for Malaria, as well as drugs addressing Diharrea and Chagas, all three of which would be 'breakthrough' drugs.
Also, I do recall reading that Big Pharma spends
tons of money each year wining and dining doctors in order to get them to prescribe more of their drugs. This cost gets passed right along to the consumer.
Not to mention the fact that Big Pharma has spent more money on stock dividends in the last few years than they have on R&D; it is painfully obvious that these companies, which purport to support Human Health, are interested in making a profit and little else.
There are other ways of doing things.
Cycloptichorn