@realjohnboy,
I am not sure if I fully understand...but you are asking me what strategies I use if I get one of those draft positions? I honestly think that being in the middle is very good...Or either end...unless there are say 14 teams or more and then the back end is not really good...because you will get first or second picks in alternate rounds, but you lose out a lot in that first round...
I usually go one batter, one pitcher, one batter, one pitcher...Unless there is a great bat or pitcher out there, and I will take 2 in a row...I never draft high closers, unless I wanted to grab Kimbrel, but then I will not draft closers for awhile...
I map out all the closers at the start of the season...and I grab a couple solid ones, and then I grab 2 that will get saves but may not have great stats...because all you are taking them for is the saves...
I usually always go for pitchers who have low era's, and almost 1 K per inning...I try to stay away from high whip's...but most k guys may be wild and have higher whips...
I do not pay a ton of attention to wins...because if I think my pitchers may not get that many...I will just make sure I grab another reliable arm in the middle of the draft...
Most leagues it pays to always go for bats and not arms, because a solid bat will give you usually 4 categories...and you can get bench guys for SB's...all pitchers will only give you a max of 3, since SP do not get saves...In standard formats...
But in my opinion, it is also hardest to have good pitching if you do not grab at least 2 or 3 really good arms...because pitching is the hardest to predict...
I usually never pay much attention to the SB category...that and saves are the most over rated stat...and if I am lacking in either...I will grab a ham and egg closer...And I will grab a free agent who does nothing but runs to try to grab a couple of points, or always keep me in the hunt for the league match-ups...
I get a feel for who I want to take when it is 3 spots before mine, and I always try to find an alternative in case they are taken...and I judge how good I think each player will do by looking over what they have done in the last 2 seasons...