Although I didn't particularly care for the movie, it was unusual to see Harrison Ford as a villain in What Lies Beneath; not his best performance, however.
I'll second Mr. Wizard's observation about Agnes Moorehead in Hush, Hush, Sweet Charlotte. Great!
Wish I could remember the name of the movie in which Samuel Jackson was a fantastic villain.
Fantastic-villain. Is that an oxymoron?
Great thread, Booman.