@roger,
As you know, Rog, this aint the first time that uppity states have tried to systematically undermine federal law. Many southern states did their best to subvert, impede, and ignore laws regarding school integration and other civil/constitutional rights.
I don't recall any cheese-eaters arguing at that time that if a state didn't like a federal law, then it was free to ignore and violate it.
Needless to say, it has never been a "defense" to violating law for the criminal to say he doesn't "agree" with it.
No one give's a rat's ass if Jose, and all his cheese-eating fellow travelers, doesn't like U.S. law or thinks it's somehow "unfair."