For three decades, Old Man selflessly helped scientists unravel the mysteries behind Alzheimer's, osteoporosis, cancer and other age-related diseases.
Born in Kenya, he lived an active life — including siring offspring — until early Thanksgiving morning, when his body was discovered in a lab at the Barshop Institute for Longevity and Aging Studies on the campus of the Texas Research Park in Bexar County.
A naked mole rat, Old Man was believed to be 32.
Often called the ugliest animals on the planet, naked mole rats are positively beautiful in the eyes of researchers on aging such as Rochelle Buffenstein, a professor in the department of physiology.
"In many ways, they confound what scientists think they know about how diseases progress and why living things age," she said.
The Barshop Institute, part of the University of Texas Health Science Center, maintains the world's largest mole rat colony. About 2,000 of the tiny, burrowing rodents whose most distinctive feature is their sharp, protruding teeth, live and breed in four basement labs. With their long, hairless bodies and translucent pink skin, they look a bit like Vietnamese spring rolls with legs.
Because these natives of East Africa live an average 26 years (compared to the 2- to 4-year lifespan of other rodents), they're well suited for studies of age-related disease.