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COUMADEN AND ME

 
 
Reply Sat 25 Aug, 2007 07:40 am
Had to interrupt vacation a bit when I started in another bout of atrial fibrillation. So I had some cleinet work in Philly anyway so we flew down to LAnkanau hospital (big heart center near philly).
Yep, my blood is still csrewed up in the electrolyte department and , since the AtFib is ongoing, (the doctors arent as concerned about it as a condition as they are about the possibility of me stroking out) SO, they put me on 5mg of Coumaden per day.

Ive read theliterature and the webon warfarin and am amused that the powers of coumaden were noted just in the me accidental fashion as was nitroglycerine.

Back to the point, Ill be sensitive About watching foods high in vitamin K, sooo, Im not gonna miss stuff like broccoli.

ANYBODY have a familiarity with coumaden maintenance and dos and donts,
My new doc is a "Rhythm specialist". They want to get the blood thinner in effect then they will work on whether my heart rhythm problems can be treated with meds or some surgery.
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Type: Discussion • Score: 2 • Views: 9,941 • Replies: 130
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dlowan
 
  1  
Reply Sat 25 Aug, 2007 08:04 am
Oy...no info, sorry, but I do hope you benefit from this new treatment and doctor.
0 Replies
 
Phoenix32890
 
  1  
Reply Sat 25 Aug, 2007 08:13 am
What I DO know, is that certain foods and supplements are blood thinners, so you want to be careful about them. Aspirin, glucosamine chondroitin MSM, ginkgo biloba, ibuprofen, fish oil, Vitamin E, and Percodan are a few that come to mind. There are a lot of medications that are combos which contain iboprofen or aspirin. Check your bottles. It is very important to have your PT time checked on a regular basis.

This looks like a pretty good site, with some helpful links:

http://members.aol.com/AMAmail/Coumadin.html
0 Replies
 
happycat
 
  1  
Reply Sat 25 Aug, 2007 08:17 am
I'll second dlowan's post, farmerman! Smile
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edgarblythe
 
  1  
Reply Sat 25 Aug, 2007 08:17 am
Make it a threezy.
0 Replies
 
farmerman
 
  1  
Reply Sat 25 Aug, 2007 08:38 am
Thanks fer the links and the wishes. Im pretty good on the knowledge of the other "blood thinner substances" What Im now needing is more information on foods to AVOID because they ate coumaden antagonists (like foods high in vitamin K). which would undo any potential that coumaden is affording me.
0 Replies
 
Phoenix32890
 
  1  
Reply Sat 25 Aug, 2007 08:41 am
Here ya go!

http://www.vaughns-1-pagers.com/food/vitamin-k-foods.htm
0 Replies
 
farmerman
 
  1  
Reply Sat 25 Aug, 2007 09:04 am
EGG YOLKS!!! Shocked

My once a week breakfass of bacon eggs homey fires and buttered white toast is now OUT ?
Oh just shoot me!
0 Replies
 
Phoenix32890
 
  1  
Reply Sat 25 Aug, 2007 09:13 am
Quote:
Noodles, egg, spinach, cooked, enriched
162
160
1 cup


I think that they were referring to egg noodles. I'll check some more. Hang in, and don't be moved to hysteria! Laughing
0 Replies
 
Phoenix32890
 
  1  
Reply Sat 25 Aug, 2007 09:19 am
This is from the Mayo Clinic, which is about as close to "the horse's mouth" that you can get. They don't get into a snit about eggs.

Quote:
Limit foods that are high in vitamin K, such as:

Kale
Spinach
Turnip greens
Collards
Swiss chard
Parsley
Mustard greens
In addition to foods containing vitamin K, certain beverages can increase the effect of warfarin, leading to bleeding problems:

Cranberry juice
Alcohol


http://www.mayoclinic.com/health/warfarin/AN00455

Also, take a look at supplements you should avoid:

http://www.mayoclinic.com/health/coumadin/AN01652
0 Replies
 
Noddy24
 
  1  
Reply Sat 25 Aug, 2007 10:08 am
Farmerman--

Mr. Noddy's been on Coumadin for donkey's years. He's prone to bouts of retinal bleeding and assorted colorful bruises, but this is better than a fatal stroke.

Real Men don't eat greens anyway.

Hold your dominion.
0 Replies
 
littlek
 
  1  
Reply Sat 25 Aug, 2007 05:03 pm
Dammit! Farmerman, you better take care of yourself.
0 Replies
 
farmerman
 
  1  
Reply Sat 25 Aug, 2007 05:11 pm
The fact is, the doctors on my cae, including the rhythm guy, isnt worried about the arhythmia. They are worried at the possibility of having a stsroke in my 50's so I take the coumaden.

Its funny that, when it first started happening the arrhythmia was very scary and after Id been checked over enough and declared not a danger to myself (with the exception of the clotting thingy) Its actually dcreased a lot and my rhytm guy says that this may be my body's way of dealing with stress.
They have so many meds fo0r rhythm control that they are waiting until I establish a maintenance doe of coumaden , then they will get to work on the arhythmia.
0 Replies
 
DrewDad
 
  1  
Reply Sat 25 Aug, 2007 05:39 pm
Ain't it great to be told to take rat poison?





Avoid Mexican vanilla; they use coumarin (a warfarin precursor) instead of alchohol to extract the flavor from the beans.
0 Replies
 
Tai Chi
 
  1  
Reply Sat 25 Aug, 2007 05:41 pm
Don't eat anything that might have eaten a mouse that might have eaten warfarin.

(And take care of yourself, for pete's sake!)
0 Replies
 
farmerman
 
  1  
Reply Sun 26 Aug, 2007 05:00 am
Ill have to take that vanilla thing into consideration because we buy lots of Mexican Vanilla (its so damn cheap).
0 Replies
 
ehBeth
 
  1  
Reply Sun 26 Aug, 2007 06:40 pm
brenda lee's daughter was just put on the same meds. I'll check my work email tomorrow, as b-l sent me a list of things her daughter was told to avoid - other than the obvious leafy greens.

I do recall reading that quinoa's also part of that same group of plants - and not to be in your diet when you're taking coumadin.
0 Replies
 
Miller
 
  1  
Reply Sun 26 Aug, 2007 07:02 pm
Information for Anticoagulation Patients

Click here to see the Web Seminar - Coumadin (warfarin) Genetics

Every day millions of people take warfarin or Coumadin, powerful drugs used to control life threatening conditions. How much of these medicines people need is difficult to determine and often it takes several months of weekly clinic visits and blood tests.

According to the FDA, hemorrhage during warfarin therapy is a leading cause of death in Western countries and related adverse events account for 1 in 10 hospital admissions. Click here to see the FDA slides.

Thankfully, recent discoveries in DNA research make predicting the dose of warfarin a person needs much more accurate, and of equal importance, how long it takes them to eliminate the drug. More than half the population have variations in at least one of the two genes that are tested. These genetic variations are responsible for almost half of the individual variation seen in warfarin dose.


Here's what a blue ribbon FDA advisory panel has to say about the genetics of warfarin/Coumadin:

* Use lower doses of warfarin for patients with genetic variations in CYP2C9 and or VKORC1 that lead to reduced activities.

* Genotyping patients at the begining of warfarin therapy would reduce adverse events and improve achievement of stable INR.

* Existing evidence of the influence of CYP2C9 and VKORC1 genotypes warrants re-labeling of warfarin to include genetic test information.

The FDA and others are sponsoring clinical trials to prove the extent to which using DNA testing will reduce adverse bleeding events and save money. Many scientists believe that the use of this testing will dramatically improve Warfarin efficacy and safety. In the meantime you can order these tests now, share the results with your doctor and know that you're taking advantage of the most recent scientific discoveries.

Frequently Asked Questions

Do I need a prescription to order this testing?
No, a prescription is not needed.
The following information is provided by Dr. Mark Linder and Dr. Kristen Reynolds.

How are patients currently managed on warfarin therapy?
Coumadin (warfarin) is the most commonly prescribed anticoagulant for the treatment and prevention of thromboembolic events. The dose of warfarin required to maintain a safe degree of anticoagulation ranges from 2 mg/day or lower for some individuals to 10 mg per day or higher for others. Patients who are not taking the dose that is right for them are at an increased risk for severe toxicity or an inadequate response.

Currently, clinicians anticipate maintenance dose requirements based on the patients physical characteristics such as age, gender and weight and monitor the therapeutic effects closely by measuring the INR. However these physical characteristics do not account for the major sources of variation in dose requirement. Therefore the clinician must adjust the warfarin dosage when the INR is not within the safe range for anticoagulation. This can be a lengthy trial and error process where the patient is at increased risk until the most appropriate dosage for that patient is determined.

How does an individual's genetic make-up effect how much warfarin should be administered?
In addition to the physical characteristics mentioned above, functional characteristics also influence the most appropriate dose of warfarin. The major functional characteristics which influence the warfarin dose are how rapidly the individual metabolizes warfarin and how much warfarin is required in the body to inhibit to formation of clotting factors. These characteristics can not be assessed without specific diagnostic testing.

The active component of warfarin is metabolized by cytochrome P450 2C9 (CYP2C9). Up to 35% of the population inherits a form of the CYP2C9 gene which results in a CYP2C9 enzyme deficiency. A deficiency in CYP2C9 causes slow metabolism and higher than expected concentrations of the active drug to accumulate. This increased warfarin concentration in the body increases the risk of bleeding.

Warfarin inhibits the formation of active clotting factors by inhibition of vitamin K epoxide reductase complex subunit 1 (VKORC1). Inherited differences in VKORC1 increase or decrease the amount of warfarin needed to inhibit the formation of the clotting factors. When the amount of warfarin exceeds what is needed, the risk of bleeding is increased.

How can this information be applied?
The difference in warfarin dose that is affected by the patient's metabolism or the amount of drug needed for effect do not become apparent until the four to fifth day of therapy (Peyvandi F et al. Clin Pharm Ther 2004;75:198-203). Therefore, standard approaches to initiating treatment do not need to be postponed. A sample of blood can be collected for determination of CYP2C9 and VKORC1 status on the first day of therapy. Preferably the results of testing should be applied to dose selection on or shortly after the fifth day of therapy.

What is the scientific community saying about these services?
In November of 2005, the clinical pharmacology advisory committee reporting to the FDA reviewed the current literature surrounding the application of CYP2C9 and VKORC1 testing to treatment of patients with warfarin. At that meeting, the committee unanimously agreed that "Â…sufficient mechanistic and clinical evidence exists to support the recommendation: to use lower doses of warfarin for patients with genetic variations in CYP2C9 and or VKORC1 that lead to reduced activities". And genotyping patients in the induction phase of warfarin therapy would reduce adverse events and improve achievement of stable INR? Eight out of ten committee members agreed "Â…that existing evidence of the influence of CYP2C9 and VKORC1 genotypes warrants re-labeling of warfarin to include genomic and test information."

Based on official meeting transcripts which can be found at: http://www.fda.gov/ohrms/dockets/ac/cder05.html#PharmScience

Is this testing likely to be cost effective?
There is a high likelihood that this testing will improve patient safety while providing significant savings to the healthcare system. Recent reports indicate that 70 to 100 severe bleeding events occur each year for every 1000 patients treated with warfarin (Higashi et al. JAMA 2002;287:1690-98; Margaglione M et al. Thromb Haemost 2000;84:775-8). Each of these events can result in an average hospital stay of 6 days and average healthcare costs of $16,000.00 for each event (Fanikos J et al Am J Cardiology 2005;96:595-8). PGXL charges $35.00 to process the sample, $ 266.00 for each CYP2C9 and VKORC1 test thus the total cost of testing is $ 567.00. If we apply this to a patient population of 1000 patients treated for a year, cost effectiveness will be achieved if 33 to 47% of the anticipated number of bleeding events are avoided. Any events avoided beyond this will have obvious positive benefits for the patient and directly reduce the financial burden on the healthcare system.

Are these laboratory services covered by health insurance?
This year, the American Medical Association (AMA) recommended to the Centers for Medicare & Medicaid Services (CMS) to establish CPT codes and reimbursement schedules which can be applied to pharmacogenetic diagnostics. The appropriate coding is dependent upon the technology used by the laboratory. The anticipated reimbursement is 70% of the total charge. Private insurance companies such as Anthem, Humana and others (By Lisa Barrett Mann, Special to The Washington Post, Tuesday, April 18, 2006; Page HE01) have covered costs for testing for the majority of our clients who submitted for coverage.


Disclaimer

The content of this web site is for public use, free of charge, and for information only. It is not intended to be used in any other way. The authors disclaim any liability, loss, injury, or damage incurred as a consequence, directly or indirectly, of the use and application of any of the content of this web site.

The information presented on this site is intended as general health information and as an educational tool. It is not intended as medical advice. Only a physician, pharmacist, or other healthcare professional should advise a patient on medical issues and should do so using a medical history and other factors identified and documented as part of the health professional/patient relationship.

Founded in 1987, Genelex Corporation has been accredited by the AABB Parentage Testing Committee in DNA parentage testing since 1992, is Washington State Medical Test Site No. MTS-3919 CLIA No. 50D0980559, and has contributed to the validation of National Institute of Standards and Technology (NIST) Standard Reference Materials.

3000 First Ave. Ste. One Seattle, WA 98121
800 523-3080
Genelex Corporation. A

www.healthandDNA.com

( I removed the advertisements that accompanied this article)
0 Replies
 
farmerman
 
  1  
Reply Sun 26 Aug, 2007 10:27 pm
thanks Miller, Im going to forward that to the cardiologist whose leading the charge.

I dont have my INR down but have gone on 5mg then down to 2 after 3 days and then a blood test on Thurs. Im planniong subsequent blood tests in MAine and am not hanging here longer than I have to.
0 Replies
 
Miller
 
  1  
Reply Mon 27 Aug, 2007 06:18 pm
Most vials of this med, now contain the information about
"genetics".
0 Replies
 
 

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