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Taking Rx at different time of day

 
 
Reply Sat 1 Feb, 2003 12:18 am
There's been a recent report that taking medication at different time of day can effect its potency or effectiveness. Anybody out there know anything about this? c.i.
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Type: Discussion • Score: 1 • Views: 4,257 • Replies: 50
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roger
 
  1  
Reply Sat 1 Feb, 2003 12:48 am
No, but I'm certainly interested. I also have questions on the effects relative to the timing of medication and meal times.
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New Haven
 
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Reply Sat 1 Feb, 2003 07:32 am
That kind of a situation will depend on the specific drug and its accompanying bio-pharmaceutics. Some meds are to be taken in the morning prior to food. Others are to be taken in the pm prior to bed.

The side effects are ciritical in the determination of time as well as the kinetic properties of specific drug metabolism.
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New Haven
 
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Reply Sat 1 Feb, 2003 07:33 am
Did you know that the most common time for heart atttack is early am.
About 4-7 am. There is a metabolic reason for this.
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Steve 41oo
 
  1  
Reply Sat 1 Feb, 2003 07:41 am
well what is it?

why do I get the impression you have no idea what you are talking about?
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Phoenix32890
 
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Reply Sat 1 Feb, 2003 07:42 am
New Haven- Right. In addition, some prescriptions are not to be taken with food, and with others it does not matter. Then again, other medications, especially those which have a potential for adverse GI problems, must be taken with food.

C.I.- I have heard about the report that you have mentioned, but I can't seem to find it. I think that it is something that the subject is in an area that is important for people to know.
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New Haven
 
  1  
Reply Sat 1 Feb, 2003 07:43 am
Steve:

Could you please clarify your last comment?
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New Haven
 
  1  
Reply Sat 1 Feb, 2003 07:46 am
Phoenix:

This is one area of pharmaceutical research which is rarely studied. More likely to study the influence of the circadian cycle (light/dark) on drug metabolism because of it's influence on microsomal metabolism.
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Phoenix32890
 
  1  
Reply Sat 1 Feb, 2003 08:06 am
Steve-
Check this out:[/color]

Link to Heart Attack Article


Note this paragraph:

Quote:
Another thing to pay attention to, he says, is the time you are experiencing symptoms. Because most heart attacks take place between 4 a.m. and 10 a.m. when blood pressure fluxes are most dramatic, it's especially important to respond immediately if you are awakened by inexplicable or unfamiliar pains.


I know that this is a popular article, but it DOES confirm what New Haven says. If you want to delve deeper, I am sure that you could find a more medically oriented article through surfing the medical journals!
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New Haven
 
  1  
Reply Sat 1 Feb, 2003 08:10 am
Phoenix:

Good follow up! Very Happy
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Phoenix32890
 
  1  
Reply Sat 1 Feb, 2003 08:10 am
New Haven- I know that this is getting a little off the subject, but there HAVE been studies of increased accidents in people who work the night shift. From what I remember, the conclusions also were related to the circadian cycle!
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New Haven
 
  1  
Reply Sat 1 Feb, 2003 08:13 am
Phoenix:

I think I've seen those reports. These studies are very relevant to jobs that require a 24/7 operation, such those associated with ER work.
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Phoenix32890
 
  1  
Reply Sat 1 Feb, 2003 08:44 am
This is getting more and more fascinating:


Link to Article on Body Clock
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New Haven
 
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Reply Sat 1 Feb, 2003 08:46 am
Phoenix:

Thanks for link. Very Happy
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cicerone imposter
 
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Reply Thu 6 Feb, 2003 01:38 pm
Phoenix, Are you sure we want to increase the world population? LOL c.i.
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Phoenix32890
 
  1  
Reply Thu 6 Feb, 2003 01:50 pm
c.i.- I don't think that we are in TOO much trouble. In the places in the world where overpopulation is a great concern, I don't think that people are reading the link on the internet! Very Happy
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New Haven
 
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Reply Thu 6 Feb, 2003 02:19 pm
Phoenix:

One never knows!
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cicerone imposter
 
  1  
Reply Thu 6 Feb, 2003 03:52 pm
Phoenix, I don't know about that! China and India both have computers and the internet. Wink c.i.
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williamhenry3
 
  1  
Reply Thu 6 Feb, 2003 06:44 pm
My pharmacy usually supplies a hand-out about the drug when I get the prescription filled. Most of these handouts advise taking the drug at same time every day so you'll remember to take it.

On the web, I often check www.webmd.com for its comments on a particular drug. Very helpful. :wink:
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mamajuana
 
  1  
Reply Thu 6 Feb, 2003 09:50 pm
From personal experience - I take several medications regularly, all of which come with varying directions on time, foods, etc. All of it very taxing to my memory. So I asked my internist and my cardiologist. Their advice to me was to take everything in the morning (or at some other time of day). The rationale: consistency in the time of taking, and a surety that they will be taken. They say they have many patients who forget, or vary the times, or get so upset about eating, not eating, etc with the meds that they just don't. My doctor feels that if you get half the benefits, it's better than no benefits. So that's the regimen I've followed, and it works very well for me. One of the things is the interaction of grapefuit juice with cholesteral meds. Here I learned that it's okay if you wait 2-3 hours.

I speak only for me, of course. But having read all the caveats, I did discuss with my doctors. (And with my son, who is a chemist and has worked with pharmaceuticals.)
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