Reply
Sat 1 Feb, 2003 12:18 am
There's been a recent report that taking medication at different time of day can effect its potency or effectiveness. Anybody out there know anything about this? c.i.
No, but I'm certainly interested. I also have questions on the effects relative to the timing of medication and meal times.
That kind of a situation will depend on the specific drug and its accompanying bio-pharmaceutics. Some meds are to be taken in the morning prior to food. Others are to be taken in the pm prior to bed.
The side effects are ciritical in the determination of time as well as the kinetic properties of specific drug metabolism.
Did you know that the most common time for heart atttack is early am.
About 4-7 am. There is a metabolic reason for this.
well what is it?
why do I get the impression you have no idea what you are talking about?
New Haven- Right. In addition, some prescriptions are not to be taken with food, and with others it does not matter. Then again, other medications, especially those which have a potential for adverse GI problems, must be taken with food.
C.I.- I have heard about the report that you have mentioned, but I can't seem to find it. I think that it is something that the subject is in an area that is important for people to know.
Steve:
Could you please clarify your last comment?
Phoenix:
This is one area of pharmaceutical research which is rarely studied. More likely to study the influence of the circadian cycle (light/dark) on drug metabolism because of it's influence on microsomal metabolism.
New Haven- I know that this is getting a little off the subject, but there HAVE been studies of increased accidents in people who work the night shift. From what I remember, the conclusions also were related to the circadian cycle!
Phoenix:
I think I've seen those reports. These studies are very relevant to jobs that require a 24/7 operation, such those associated with ER work.
Phoenix, Are you sure we want to increase the world population? LOL c.i.
Phoenix:
One never knows!
Phoenix, I don't know about that! China and India both have computers and the internet.
c.i.
My pharmacy usually supplies a hand-out about the drug when I get the prescription filled. Most of these handouts advise taking the drug at same time every day so you'll remember to take it.
On the web, I often check
www.webmd.com for its comments on a particular drug. Very helpful. :wink:
From personal experience - I take several medications regularly, all of which come with varying directions on time, foods, etc. All of it very taxing to my memory. So I asked my internist and my cardiologist. Their advice to me was to take everything in the morning (or at some other time of day). The rationale: consistency in the time of taking, and a surety that they will be taken. They say they have many patients who forget, or vary the times, or get so upset about eating, not eating, etc with the meds that they just don't. My doctor feels that if you get half the benefits, it's better than no benefits. So that's the regimen I've followed, and it works very well for me. One of the things is the interaction of grapefuit juice with cholesteral meds. Here I learned that it's okay if you wait 2-3 hours.
I speak only for me, of course. But having read all the caveats, I did discuss with my doctors. (And with my son, who is a chemist and has worked with pharmaceuticals.)