Unless they're incompetent and you've got Power of Attorney, then no, you're not responsible for these grownups in name only.
If you want a more official pronouncement, consult a lawyer. Do you need to keep the peace in the family? Well, it's a nice idea in theory, but you don't need to bother.
You can even stop talking to them. Forever. Really. Lots of people cease all contact with family members that are toxic, as it seems these people are.
I'm sorry this is happening. Can you attempt to have a relationship with even one of them, if you lay the ground rules immediately and firmly? If you can't, then you can't, but if family is important to you then you might want to at least try. But you don't need to bend over backwards. It's more like, "Sis (or whoever you choose who you think will be most amenable to this), I love you but you need to stand on your own two feet now. I can't continue to support you financially. Here are some places you can go to look for work or get emergency funds or find a cheap apartment (or whatever you find for her). I wish you all the best."
And then wash your hands of it. A truly spoiled brat will scream and complain about this. A person with a shred of self-respect will thank you and try to become independent (and there's nothing wrong with trying to help someone who is trying, but just isn't successful. That does happen, of course). It may take a while for this person to come around, and if they do, great. But if they never do then you have done all you can and can hold your head high.
You need not bankrupt yourself just because everyone around you can't get their **** in gear.