Before taking prednisone
You should not use this medication if you are allergic to prednisone, or if you have a fungal infection anywhere in your body.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
To make sure prednisone is safe for you, tell your doctor if you have:
any illness that causes diarrhea;
liver disease (such as cirrhosis);
heart disease, high blood pressure, low levels of potassium in your blood;
a thyroid disorder;
a history of malaria;
glaucoma, cataracts, or herpes infection of the eyes;
stomach ulcers, ulcerative colitis, or a history of stomach bleeding;
a muscle disorder such as myasthenia gravis; or
depression or mental illness.
Prednisone side effects
Get emergency medical help if you have any of these signs of an allergic reaction to prednisone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
blurred vision, eye pain, or seeing halos around lights;
swelling, rapid weight gain, feeling short of breath;
severe depression, feelings of extreme happiness or sadness, changes in personality or behavior, seizure (convulsions);
bloody or tarry stools, coughing up blood;
pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Other common prednisone side effects may include:
sleep problems (insomnia), mood changes;
increased appetite, gradual weight gain;
acne, increased sweating, dry skin, thinning skin, bruising or discoloration;
slow wound healing;
headache, dizziness, spinning sensation;
nausea, stomach pain, bloating; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.