5
   

On medication? Stay off the grapefruit.

 
 
Reply Tue 27 Nov, 2012 05:08 am
Just read this the other day, who would have thought that grapefruit could be so dangerous?

Quote:
Doctors have warned of a "lack of knowledge" about the dangers of mixing some medications with grapefruit.

The fruit can cause overdoses of some drugs by stopping the medicines being broken down in the intestines and the liver.

The researchers who first identified the link said the number of drugs that became dangerous with grapefruit was increasing rapidly.

They were writing in the Canadian Medical Association Journal.

The team at the Lawson Health Research Institute in Canada said the number of drugs which had serious side effects with grapefruit had gone from 17 in 2008 to 43 in 2012.

They include some drugs for a range of conditions including blood pressure, cancer and cholesterol-lowering statins and those taken to suppress the immune system after an organ transplant.

Chemicals in grapefruit, furanocoumarins, wipe out an enzyme which breaks the drugs down. It means much more of the drug escapes the digestive system than the body can handle.


http://www.bbc.co.uk/news/health-20497086
  • Topic Stats
  • Top Replies
  • Link to this Topic
Type: Discussion • Score: 5 • Views: 1,992 • Replies: 20

 
farmerman
 
  2  
Reply Tue 27 Nov, 2012 07:06 am
@izzythepush,
I wonder whether, say, justfor a story line, If someone wanted to like, do somebody harm, like say murder them, I wonder whether using a grapefruit overdose would be detectable by forensic means?.
Mame
 
  1  
Reply Tue 27 Nov, 2012 07:50 am
@farmerman,
How would they prove you a) knew about the grapefruit link, and b) gave it to the dead person? You could say you warned them not to take it but they wouldn't listen.
0 Replies
 
JPB
 
  3  
Reply Tue 27 Nov, 2012 07:52 am
I'd rather eat the grapefruit and stay off medicines.
ehBeth
 
  1  
Reply Tue 27 Nov, 2012 08:01 am
@JPB,
Given that some of the meds are related to organ transplants and cancer treatment, I'd defer on the grapefruit if I was on any of the listed meds.

There's been a lot of coverage in the medical community up here about the dangers of grapefruit/grapefruit juice for at least 15 years. The official list is bigger now than it was a few years ago, but it's been standard practice for pharmacists to warn people about the possible problems with an even larger list of meds.
izzythepush
 
  1  
Reply Tue 27 Nov, 2012 08:51 am
@ehBeth,
ehBeth wrote:

There's been a lot of coverage in the medical community up here about the dangers of grapefruit/grapefruit juice for at least 15 years.


It's the first I'd heard of it, but the research was carried out where you are. It would never have crossed my mind that grapefruit could be harmful, anything that tastes that sour must be good for you.
PUNKEY
 
  1  
Reply Tue 27 Nov, 2012 08:55 am
I understand that lemons and celery act the same.
ossobuco
 
  1  
Reply Tue 27 Nov, 2012 09:58 am
That BBC article Izzy linked also mentioned Seville oranges, and the fact they are used in a lot of marmalades.

I take little medication (luck, mostly) and always research the drug and ask pharmacist about interactions. That's one thing the internet is a big help about, though of course information isn't always correct.
farmerman
 
  2  
Reply Tue 27 Nov, 2012 09:58 am
@PUNKEY,
wow, mame, I have a short story but its set back in time when beta blockers and ACE inhibitors first came out.
0 Replies
 
izzythepush
 
  2  
Reply Tue 27 Nov, 2012 10:30 am
@ossobuco,
ossobuco wrote:

That BBC article Izzy linked also mentioned Seville oranges, and the fact they are used in a lot of marmalades.


Of course, it's the BBC after all.

ehBeth
 
  1  
Reply Tue 27 Nov, 2012 10:47 am
@izzythepush,
this is about research published in 2004

http://www.urmc.rochester.edu/news/story/index.cfm?id=720

Quote:
Interactions between grapefruit juice and medications have long been recognized. Last year, the Medical Letter on Drugs and Therapeutics devoted an entire issue to grapefruit juice and the dangerous drug interactions that can result. The U.S. Food & Drug Administration requires all prospective new drugs that are thought to interact with this enzyme system to be tested for interactions with grapefruit juice. And a warning about grapefruit juice is included in the “food-drug interactions” that come with dozens of medications.


Quote:
Drugs that use the same pathway and interact with grapefruit juice target some of the most common health problems doctors see today. The list consists of more than 50 medications, including some drugs used to treat high cholesterol, depression, high blood pressure, cancer, depression, pain, impotence, and allergies.

Karch notes that interactions with grapefruit juice are well known and documented among drug researchers, and that an appropriate warning label is included with each prescription. Nevertheless, she says that many patients, nurses and doctors aren’t aware of the interactions or the potential serious consequences, and that many people fail to read the warning labels about drug-food interactions.



this references published research in the area of grapefruit/grapefruit juice going back to the early 1980's. there seems to have been a lot of activity in that area of research in the mid-1990's

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1873672/
ossobuco
 
  1  
Reply Tue 27 Nov, 2012 11:49 am
@izzythepush,
like that!
0 Replies
 
izzythepush
 
  1  
Reply Tue 27 Nov, 2012 12:13 pm
@ehBeth,
I wasn't doubting you before, I don't tend to read a lot of medical journals.
farmerman
 
  2  
Reply Tue 27 Nov, 2012 12:22 pm
@izzythepush,
nevertheless , thi was old news. I think we discussed it here many moons ago
amygarside
 
  1  
Reply Tue 27 Nov, 2012 06:19 pm
@izzythepush,
Thank you for sharing this information. This is something to think about when eating grapefruit.
0 Replies
 
ehBeth
 
  1  
Reply Tue 27 Nov, 2012 08:25 pm
@izzythepush,
Not so much 'proving it', but putting it into context for myself.

I knew that it had been a regular point of discussion with docs and pharmacists over the years - hamburgboy has talked about it as well with different meds he and mrs hamburger were prescribed over the years.

It is such a normal thing to be aware of - I wondered how long the knowledge had been out there. I can't control the research nerd in my soul.
0 Replies
 
ossobuco
 
  1  
Reply Tue 27 Nov, 2012 08:37 pm
@farmerman,
I remember that, but more doesn't hurt.
0 Replies
 
chai2
 
  1  
Reply Tue 27 Nov, 2012 08:54 pm
wow, I know this from first hand experience.

I once bought a bag of grapefruits, and the first one was so delicious, I ended up cutting up and eating a couple more.

Then I took my zoloft.

I got the sweats, was very shaky for a while. Not a nice experience.

I haven't eaten any, or had its juice since.
0 Replies
 
edgarblythe
 
  1  
Reply Tue 27 Nov, 2012 08:55 pm
I love grapefruit but I rarely eat it, because it has an air of unpredictability. Since I am not on any sort of medication, it may seem foolish to be that cautious, but that's the way I do things.
ossobuco
 
  1  
Reply Tue 27 Nov, 2012 09:18 pm
@edgarblythe,
I expect people who farm grapefruit will be in a lot of trouble after this.

I think it is important to pinpoint (as some link I saw but didn't snag) just what kind of drugs grapefruit interferes with. Whatever link I saw was quite specific.

I don't like rumor ruining.
0 Replies
 
 

Related Topics

Immortality and Doctor Volkov - Discussion by edgarblythe
Sleep Paralysis - Discussion by Nick Ashley
On the edge and toppling off.... - Discussion by Izzie
Surgery--Again - Discussion by Roberta
PTSD, is it caused by a blow to the head? - Question by Rickoshay75
THE GIRL IS ILL - Discussion by Setanta
 
  1. Forums
  2. » On medication? Stay off the grapefruit.
Copyright © 2021 MadLab, LLC :: Terms of Service :: Privacy Policy :: Page generated in 0.05 seconds on 04/14/2021 at 04:46:22