Drive a bunch of cars (and trucks - I like 'em too) so that you know what to expect. Hit every likely dealership even if you don't plan to buy from them. Dealerships help if you need financing, deal with the licensing & transfer issues, and you can sometimes get a warranty. When you're talking to the sales staff... ALWAYS be willing to walk away from whatever deal they're offering. It is fun to bring a second person and do the car-buying version of Good Cop-Bad Cop. Get your stories straight. He/she loves the car... you see everything wrong. It can be very effective at a better price.
Montana mentioned her mechanic. The most important thing, I think, is to know who is going to fix the vehicle. Not only that, if you are friends with a mechanic, they'll likely know of cars that are available. One reason I like Volvos is I know a good independent Volvo mechanic.
That said, my d. LOVES her 5-speed '97 Altima. I loved my '94 Accord and when we sold it, the guy who bought it used to stop us on the street to thank us for such a great car. Economical & fun to drive, both.
Most important... always be willing to walk away. There is always another car. Second most... recognize when it is the right car and be willing to buy it on the spot.
You can check eBay for real car pricing in your area. And you can subscribe for a month to an internet service that will check an unlimited number of VINs & tell you if there were any problems, accidents, etc. Get a car you like. You're going to spend so much time in it that you might as well enjoy the ride.
(Did anybody mention that pickups are girl magnets and everybody will start asking you to help them move?)
Here's a great car from the San Diego eBay listings... item #2456642731 for $4500 and it's just had it's 100K tune-up... the expensive timing belt one.