0
   

which = Denosumab ?

 
 
Reply Fri 25 Nov, 2011 12:02 am

Context:

Delayed Time to Metastases

The results of this study show that treatment with denosumab (120 mg subcutaneously every 4 weeks) significantly prolonged the time to first bone metastasis and was associated with fewer symptomatic bone metastases than placebo, the researchers report.

These findings provide the "first direct clinical evidence for the important role of the bone environment and RANKL signaling in the development of bone metastases in men with prostate cancer," they add.

Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B (RANK) ligand, which mediates the interaction between osteoblasts and osteoclasts in the so-called vicious cycle that characterizes bone metastases in prostate cancer, the editorialist explains.
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View best answer, chosen by oristarA
XXSpadeMasterXX
 
  1  
Reply Sun 3 Feb, 2013 01:55 am
@oristarA,
Denosumab = Prolia or Xgeva...An FDA approved drug for the treatment of bone problems...

http://www.amgen.ca/Prolia_PM.pdf

"PROLIA (denosumab) is a human IgG2 monoclonal antibody with affinity and specificity for
human RANK ligand (RANKL) that inhibits RANKL from activating its receptor, RANK, on
the surface of osteoclasts and their precursors. Prevention of RANKL-RANK interaction
inhibits osteoclast formation, function and survival, thereby decreasing bone resorption.
Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically
engineered mammalian (Chinese Hamster Ovary) cells.
PROLIA is supplied as a single use, sterile, preservative-free, clear, colourless to slightly yellow
solution formulated at pH 5.2. PROLIA is supplied in either a 60 mg/mL prefilled syringe (PFS)
or a 60 mg/mL vial

INDICATIONS AND CLINICAL USE
presentation with a 1.0 mL volume and intended for delivery by
subcutaneous injection."
oristarA
 
  1  
Reply Sun 3 Feb, 2013 02:06 am
@XXSpadeMasterXX,
Ah? Thanks.
But I knew this. My question is grammatical: which does the "which" refer to?

Context:
Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B (RANK) ligand, which mediates the interaction between osteoblasts and osteoclasts in the so-called vicious cycle that characterizes bone metastases in prostate cancer, the editorialist explains.
XXSpadeMasterXX
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  2  
Reply Sun 3 Feb, 2013 03:03 am
@oristarA,
Which = Denosumab...Yes, you were correct...Wink
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