@oristarA,
Denosumab = Prolia or Xgeva...An FDA approved drug for the treatment of bone problems...
http://www.amgen.ca/Prolia_PM.pdf
"PROLIA (denosumab) is a human IgG2 monoclonal antibody with affinity and specificity for
human RANK ligand (RANKL) that inhibits RANKL from activating its receptor, RANK, on
the surface of osteoclasts and their precursors. Prevention of RANKL-RANK interaction
inhibits osteoclast formation, function and survival, thereby decreasing bone resorption.
Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically
engineered mammalian (Chinese Hamster Ovary) cells.
PROLIA is supplied as a single use, sterile, preservative-free, clear, colourless to slightly yellow
solution formulated at pH 5.2. PROLIA is supplied in either a 60 mg/mL prefilled syringe (PFS)
or a 60 mg/mL vial
†
INDICATIONS AND CLINICAL USE
presentation with a 1.0 mL volume and intended for delivery by
subcutaneous injection."