3
   

transplanted ? I suspect it is a misuse of "rejected"

 
 
Reply Sat 22 Oct, 2011 12:16 am

Do you agree with me?

Context:

This Review will draw attention to preclinical models of transplantation from pigs to non-human primates. Much 5progress has been made in the past decade, largely because of the increasing availability of pigs that have
undergone genetic modifi cations to protect tissues to be transplanted from the human immune response (table). Generally, genetic manipulations have proved stable 10,16,24,25through several generations. However, signifi cant
barriers need to be overcome before pig organ xeno-transplantation can become a clinical therapy, although clinical trials of pig islet, neuronal-cell, and corneal xenotransplantation are imminent. A govern ment-
regulated clinical trial of pig islet transplantation is taking 26 place in New Zealand.
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Type: Question • Score: 3 • Views: 1,200 • Replies: 19

 
oristarA
 
  1  
Reply Sat 22 Oct, 2011 12:23 am
@oristarA,
Because at the begining, the author says:

Clinical xenotransplantation: the next medical revolution?

Burcin Ekser, Mohamed Ezzelarab, Hidetaka Hara, Dirk J van der Windt, Martin Wijkstrom, Rita Bottino, Massimo Trucco, David K C Cooper
The shortage of organs and cells from deceased individuals continues to restrict allotransplantation. Pigs could provide an alternative source of tissue and cells but the immunological challenges and other barriers associated with
xenotransplantation need to be overcome. Transplantation of organs from genetically modified pigs into non-human primates is now not substantially limited by hyperacute, acute antibody-mediated, or cel lular rejection, but other issues have become more prominent, such as development of thrombotic micro angiopathy in the graft or systemic consumptive coagulopathy in the recipient. To address these problems, pigs that express one or more human thromboregulatory or anti-infl ammatory genes are being developed. The results of preclinical transplantation of pig
cells—eg, islets, neuronal cells, hepatocytes, or corneas—are much more encouraging than they are for organ
transplantation, with survival times greater than 1 year in all cases. Risk of transfer of an infectious microorganism to
the recipient is small.
0 Replies
 
oristarA
 
  1  
Reply Sat 22 Oct, 2011 04:34 am
Get to the cloud.
contrex
 
  1  
Reply Sat 22 Oct, 2011 04:49 am
@oristarA,
What is your question? State it clearly.
oristarA
 
  1  
Reply Sat 22 Oct, 2011 05:24 am
@contrex,
contrex wrote:

What is your question? State it clearly.



Should "translanted" be "rejected" in the context?

The title of the thread has stated clearly:
transplanted ? I suspect it is a misuse of "rejected"
0 Replies
 
fobvius
 
  1  
Reply Sat 22 Oct, 2011 05:48 am
@oristarA,
Transplanted is used correctly.

... to protect tissues, (to be transplanted), from the human immune response ...
OmSigDAVID
 
  1  
Reply Sat 22 Oct, 2011 06:00 am
@oristarA,
oristarA wrote:


Do you agree with me?
No. Transplantation refers to removing a plant from the place in the Earth where it is growing
and planting it elsewhere, burying its roots in a new location.


This now refers to similarly removing an organ from a pig
and implanting it in a non-human primate, with the hope
that it will not be rejected. In both cases, something
is removed from its place of origin and it is implanted elsewhere.





David
0 Replies
 
oristarA
 
  1  
Reply Sat 22 Oct, 2011 06:01 am
@fobvius,
fobvius wrote:

Transplanted is used correctly.

... to protect tissues, (to be transplanted), from the human immune response ...


Do you mean in that context "tissues to be transplanted " means "transplanted tissues?"
fobvius
 
  1  
Reply Sat 22 Oct, 2011 06:09 am
@oristarA,
Yes.
oristarA
 
  1  
Reply Sat 22 Oct, 2011 06:26 am
@fobvius,
fobvius wrote:

Yes.


Thanks.

The usage is a bit weird. Because that conclusion is based on the studies done, while "to be done" is a future tense.
OmSigDAVID
 
  -2  
Reply Sat 22 Oct, 2011 06:26 am
@fobvius,
fobvius wrote:
Transplanted is used correctly.

... to protect tissues, (to be transplanted), from the human immune response ...
Note, incidentally, a very, very common pervasive error of logic
that is continually perpetrated by the most educated men, including medical doctors, to wit:
use of the word "immune" when logically, the word shoud be IMMUNITY.

As set forth in the context above,
logically it shoud say ". . . the human immunity response. . ."
and the white cells in the blood are part of the human IMMUNITY system.

It is NOT that all the systems of the human body are VULNERABLE, except one system which is "immune";
rather we refer to the system of the body that is concerned with IMMUNITY.

Accordingly, it is the immunity system,
NOT the "immune" system, as it is so very, very ofen said and written.





David
0 Replies
 
ehBeth
 
  1  
Reply Sat 22 Oct, 2011 08:20 am
@oristarA,
oristarA wrote:


Do you agree with me?



no

the use in the quoted summary is correct
0 Replies
 
dlowan
 
  2  
Reply Sat 22 Oct, 2011 08:27 am
@oristarA,
No, it means what it says....tissues to be transplanted....they have not been transplanted yet, but it is planned that they will be at a future date.
0 Replies
 
contrex
 
  2  
Reply Sat 22 Oct, 2011 12:26 pm
@oristarA,
oristarA wrote:

The usage is a bit weird. Because that conclusion is based on the studies done, while "to be done" is a future tense.


It is not weird at all. "to be done" used this way is a phrase meaning "intended to be done".
0 Replies
 
contrex
 
  3  
Reply Sat 22 Oct, 2011 12:26 pm
I wish OMsigDavid would cease prating his damned rubbish.
OmSigDAVID
 
  0  
Reply Sat 22 Oct, 2011 02:10 pm
@contrex,
contrex wrote:
I wish OMsigDavid would cease prating his damned rubbish.
Do u always GET your wishes ??

What do u think your chances are of getting it THIS time ?





David
0 Replies
 
MontereyJack
 
  2  
Reply Sat 22 Oct, 2011 03:16 pm
knowing you? zero.

what are the chances everyone is going to stop wishing precisely the same thing? zero.
ehBeth
 
  2  
Reply Sat 22 Oct, 2011 03:19 pm
@MontereyJack,
It's on my Christmas wishlist.
OmSigDAVID
 
  1  
Reply Sat 22 Oct, 2011 03:31 pm
@MontereyJack,
MontereyJack wrote:
knowing you? zero.

what are the chances everyone is going to stop wishing precisely the same thing? zero.
Instead of hurling empty personal invective
Y not express the substance of the objection? with specificity ?





David
0 Replies
 
OmSigDAVID
 
  1  
Reply Sat 22 Oct, 2011 03:32 pm
@ehBeth,
ehBeth wrote:
It's on my Christmas wishlist.
U r getting a lump of coal.
0 Replies
 
 

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