@sozobe,
Elizabeth I of England? (Very tough, thought not a pioneer of anything.)
Susan B Anthony? (Pioneer of women's rights in America)
Lise Meitner? She was a pioneer of nuclear physics, arguably contributing more for the field than any other single person. Alas, the real world is not a Hollywood morality play. Consequently, Meitner never got the Nobel Prize she deserved more than anyone else. Her career, though okay, remained far behind its potential, given her accomplishments. There isn't a single good reason for this; the only plausible reason was a bad one: Meitner was a woman. Definitely recommended if Sozlet is in feminist-avenger mode.