Blacks are mostly affected, although it is also occurs in people of Mediterranean, Middle Eastern and East Indian origin. I wonder how long it will take before they identify the genes responsible for sickle cell anemia within that gene pool.
Interestingly, "Sickle cell disease is much more common in certain ethnic groups, affecting approximately one out of every 500 African Americans. Because people with sickle trait were more likely to survive malaria outbreaks in Africa than those with normal hemoglobin, it is believed that this genetically aberrant hemoglobin evolved as a protection against malaria." Adam S. Levy, M.D., Department of Pediatrics, NYU Medical Center, New York, NY. Review provided by VeriMed Healthcare Network. (from
http://www.nlm.nih.gov/medlineplus/ency/article/000527.htm )
Also quite relevant to both this thread and the topic of sickle cell anemia:
Many Sickle Cell Kids Don't Get Antibiotics
Researchers Blame Prescription Restrictions For Trend
POSTED: 10:28 a.m. EDT August 27, 2003
CHICAGO -- A study says many children with sickle cell disease are not getting antibiotics to prevent life-threatening infections.
It has long been recommended that children with sickle cell anemia take antibiotics every day for the first five years of life. But University of Washington researchers found that children with sickle cell disease average only enough antibiotic prescriptions for about five months of the year. Ten percent received no antibiotics all, even though their disease leaves them vulnerable to infection.
The study, published in Wednesday's issue of the Journal of the American Medical Association, was based on Medicaid data for 261 children in Tennessee and Washington, but the researchers said the data probably apply nationally.
"This is a very real problem. Taking antibiotics is very important for these children; taking antibiotics protects them from catching bad infections," said lead researcher Dr. Colin Sox, a pediatrician at the University of Washington.
Insurance covered most of the prescription costs, so the researchers do not understand why the children were undermedicated.
"One possibility is that doctors are not writing the prescriptions. Another possibility is that doctors are writing the prescriptions, but the families are not filling them," Sox said. "Probably both factors contribute to what we found."
Among the complicating factors is that in both states, you can only pick up enough antibiotics to cover about 30 days at a time. Providing enough medication to protect a child from infections for a year requires repeated requests for refills and visits to a pharmacy.
"Many insurance groups, including Medicaid, place limits on the length of prescriptions. While this makes sense for some medication, it may not be best for medication that is needed for everyday use to prevent infections," Sox said.
Sickle cell disease, also called sickle cell anemia, primarily affects people of African descent, but also occurs in some people of Mediterranean, Middle Eastern and East Indian origin. The disease is caused by abnormalities of the genes of hemoglobin, the oxygen-carrying protein in red blood cells. Among blacks, one newborn in 375 develops the disease.
http://www.theksbwchannel.com/health/2436655/detail.html