My parent's wouldn't let me paint anywhere in the house, so I used to paint in the closet with the door closed
. Just enough room for three paces, a naked light bulb, and my canvas & supplies. I lost a lot of brain cells that way...
I'm really messy, so I'd also get any exposed body parts covered in paint.
Now I wear a filter mask when I paint, and I always wear latex/vinyl gloves (did you know you can absorb those toxic chemicals through your skin?). I wear a big bakery smock as a painting smock, and paint in a well lit, well ventilated area. I'm trying to preserve my brain cells as much as possible from now on!