Start Spreading the word……New York, New York

I know many people here at A2K could help with this - it should be simple. My husband has never been to New York. He is turning 40 next month and I thought a weekend in New York would be ideal. But where to stay? In the past, I have always stayed with friends on Long Island, but we would want a good location right in the city. What area do you think would be ideal to stay in? And what hotels? I don't want to spend a $1,000 a night, but want something pretty nice with deceit facilities - it is reasonable to stay in the $200 or $300 a night range and still be some one nice?