It would appear that the most successful game based on the Bible is technically The Binding of Issac
, inspired by the story of God telling Abraham to sacrifice his son Issac to test his faith.
However, the game is particularly bloody and violent. According to an interview, the creator used his experiences with his family to make the game.
""My dad's side of the family, they're all born-again Christians," says McMillen. "And with that came very little Biblical talk, but a lot of more stereotypical Christianity - the really negative aspects. Everybody's going to Hell. I'm going to go to Hell because I'm playing D&D, I'm playing Magic [The Gathering], and you're chastised for every little thing. Which is kind of ironic, because it's coming from these born-again Christians who lived the most horrible sinful lives possible before they became Christians and saved. They were all recovering alcoholics, drug addicts, everything else."
And yet, McMillen's beef is not - nor has it ever been - with Christianity. Instead, he and the Bible have an incredibly complicated relationship, built largely on both demons he's attempted to exorcise through his work and the one person who's supported that habit since day one."