Rosalind Franklin (1920 - 1958)
David Ardell --------------------------------------------------------------------------------
By 1952, much was known about DNA, including its exclusive role as genetic material - the sole substance capable of storing all the information needed to create a living being. What was not yet known was what the elusive DNA molecule looked like, or how it performed this amazing hereditary function. This would change in the course of a single year. The now familiar double helical structure of DNA, and the base-pairing crucial to its hereditary function, were deciphered in 1953, and the individuals most commonly associated with this remarkable feat are James Watson and Francis Crick. Maurice Wilkins played a crucial role as well, and he shared the 1962 Nobel Prize for Physiology and Medicine with Watson and Crick for the discovery. However, another important figure remains, without whom the discovery would not have been possible: the brilliant but short-lived Rosalind Franklin.
Born in July of 1920, Rosalind Franklin graduated from Cambridge University and in 1951 went to work as a research associate for John Randall at King's College. A chemist by training, Franklin had made original and essential contributions to the understanding of the structure of graphite and other carbon compounds even before her appointment to King's College. Unfortunately, her reputation did not precede her. James Watson's unflattering portrayal of Franklin in his account of the discovery of DNA's structure, entitled "The Double Helix," depicts Franklin as an underling of Maurice Wilkins, when in fact Wilkins and Franklin were peers in the Randall laboratory. And it was Franklin alone whom Randall had given the task of elucidating DNA's structure.
The technique with which Rosalind Franklin set out to do this is called X-ray crystallography. With this technique, the locations of atoms in any crystal can be precisely mapped by looking at the image of the crystal under an X-ray beam. By the early 1950s, scientists were just learning how to use this technique to study biological molecules. Rosalind Franklin applied her chemist's expertise to the unwieldy DNA molecule. After complicated analysis, she discovered (and was the first to state) that the sugar-phosphate backbone of DNA lies on the outside of the molecule. She also elucidated the basic helical structure of the molecule.
After Randall presented Franklin's data and her unpublished conclusions at a routine seminar, her work was provided - without Randall's knowledge - to her competitors at Cambridge University, Watson and Crick. The scientists used her data and that of other scientists to build their ultimately correct and detailed description of DNA's structure in 1953. Franklin was not bitter, but pleased, and set out to publish a corroborating report of the Watson-Crick model. Her career was eventually cut short by illness. It is a tremendous shame that Franklin did not receive due credit for her essential role in this discovery, either during her lifetime or after her untimely death at age 37 due to cancer.
http://www.accessexcellence.org/AB/BC/Rosalind_Franklin.html
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