@kish21,
You will have to be more specific.
I have given up on a marriage, a religion and a bad career choice. All of these were well worth giving up (I was much happier without them).
I have persevered on friendships, getting an education, a better career choice and raising children. All of these were well worth the effort (they made me a much happier person).
I have been on and off with fitness goals and learning music.