As a fan of nerd-dom, It doesn't really bother me when they make changes to characters whether it be race or sex. Kingpin in the comics was an overweight white guy. In the movie he was muscular tall black man. It really didn't do anything to the overall story line.
Fish Mooney wasn't in the comic books, she was created solely for the TV show Gotham.
Marvel recently re-created Thor as a woman for the comics and DC in the last few years rebooted EVERY comic they have ever created for mainstream comics, The New 52.
When it really comes down to it, as long as it works with the story they are trying to tell, then it shouldn't really matter.