Tiniest "Medical Kit" Can Fight Cancer In-Vitro

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GOOD NEWS ISRAEL
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Tiniest "Medical Kit" Can Fight Cancer In-Vitro
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The world's smallest computer (around a trillion can fit in a drop of
water) might one day go on record again as the tiniest medical kit.
Made entirely of biological molecules, this computer was successfully
programmed to identify - in a test tube - changes in the balance of
molecules in the body that indicate the presence of certain cancers,
to diagnose the type of cancer, and to react by producing a drug
molecule to fight the cancer cells.

The Weizmann Institute of Science team that developed the computer
published these results last month in Nature magazine. Headed by
Prof. Ehud Shapiro, of the Departments of Computer Sciences and
Applied Mathematics, and Biological Chemistry, the team included
research students Yaakov Benenson, Binyamin Gil, Uri Ben-Dor and Dr.
Rivka Adar. Shapiro presented the team's findings at the Brussels
symposium "Life, a Nobel Story," in which Nobel Laureates and others
addressed the future of the life sciences.

As in previous biological computers produced in Shapiro's lab, input,
output and "software" are all composed of DNA, the material of genes,
while DNA-manipulating enzymes are used as "hardware." The newest
version's input apparatus is designed to assess concentrations of
specific RNA molecules, which may be overproduced or under produced,
depending on the type of cancer. Using pre-programmed medical
knowledge, the computer then makes its diagnosis based on the
detected RNA levels. In response to a cancer diagnosis, the output
unit of the computer can initiate the controlled release of a
single-stranded DNA molecule that is known to interfere with the
cancer cell's activities, causing it to self-destruct.

In one series of test-tube experiments, the team programmed the
computer to identify RNA molecules that indicate the presence of
prostate cancer and, following a correct diagnosis, to release the
short DNA strands designed to kill cancer cells. Similarly, they were
able to identify, in the test tube, the signs of one form of lung
cancer. One day in the future, they hope to create a "doctor in a
cell", which will be able to operate inside a living body, spot
disease and apply the necessary treatment before external symptoms
even appear.

The original version of the biomolecular computer (also created in a
test tube) capable of performing simple mathematical calculations,
was introduced by Shapiro and colleagues in 2001. An improved system,
which uses its input DNA molecule as its sole source of energy, was
reported in 2003 and was listed in the 2004 Guinness Book of World
Records as the smallest biological computing device.

Shapiro: "It is clear that the road to realizing our vision is a long
one; it may take decades before such a system operating inside the
human body becomes reality. Nevertheless, only two years ago we
predicted that it would take another 10 years to reach the point we
have reached today."