@Brandon9000,
Understood, but let's forget about everyone else for the moment.
What about cover letters? Does she write them? What do they look like? Are they generic, or more tailored to each position she's applying for?
Whatever these other people are doing, the only way that applies is if they are taking jobs that your wife should have had, e. g. your wife applies and fellow student #1 does, too, and student #1 gets the job. But if your wife applies and no one from her class does, then whatever her classmates are or aren't doing does not matter here.
I would look at Monster, they do have some info on resume-writing tutorials.
The resume + cover letter + any ins she has (e. g. getting her application passed directly to the hiring manager, or having someone in her network, etc.) generally = interview or at least it can. So look at all of the components. Something isn't working, and it may be more than one thing that needs to be tweaked.