In late 2012, a United States television personality, Dr. Oz, promoted Garcinia cambogia extract as a "magic" weight-loss aid. Dr. Oz's previous endorsements have often led to a substantial increase in consumer interest in the promoted products. However, clinical trials do not support claims that Garcinia cambogia is an effective weight-loss aid. A meta-analysis found a possible small, short-term weight loss effect (under 1 kilogram). However, side effects—namely hepatotoxicity—led to one preparation being withdrawn from the market.
A 1998 randomized controlled trial looked at the effects of hydroxycitric acid, the purported active component in Garcinia gummi-gutta, as a potential antiobesity agent in 135 people. The conclusion from this trial was that "Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo.
However, side effects—namely hepatotoxicity—led to one preparation being withdrawn from the market.