@Quehoniaomath,
While you might not accept morphological changes within or across breeds as what leads to macroevolution, "the molecular sequence evidence gives the most impressive and irrefutable evidence for the genealogical relatedness of all life. The nature of molecular sequences allows for extremely impressive probability calculations that demonstrate how well the predictions of common descent with modification actually match empirical observation. Common descent is a deduction that directly follows from premises based on empirically observed molecular evidence. In addition, knowledge of biological molecular mechanisms and structures, combined with macroevolutionary theory, has given very specific, novel, and testable biomolecular predictions.".
The size differences of a teacup poodle and a great Dane are important ones as it "is extremely important for common descent, since the major morphological differences between many species (e.g. species of amphibians, reptiles, mammals, and birds) are simple alterations in size of certain aspects of their respective parahomologous structures."
