From Wired Com:
Humans, Chimps Think Different
By Kristen Philipkoski
02:00 AM Nov. 02, 2004 PT
We hear it over and over: The human and chimpanzee genomes are nearly identical. Why we look and behave so differently has been a mystery of science.
A study in the November issue of Nature Reviews Genetics offers a glimpse into the evolution of the human brain, and why we are the only benefactors of attributes like higher cognitive ability, but also unique in suffering from neurodegenerative diseases.
A group of researchers at the University of California at Los Angeles and Emory in Atlanta has compiled the first extensive analysis of human and primate genomic data. The result is a big-picture look at why human brains are so evolved. The answer lies not in which or how many genes we have, but in how and when those genes turn on and off.
"If the gene sequences themselves are very similar, then one hypothesis is that it's differences in the gene levels and regulations (that account for the differences) -- when and where they're expressed and how much," said Dr. Dan Geschwind, an associate professor of neurology and director of the neurogenetics program at the UCLA school of medicine.
Genomics technologies have made it possible to explore evolution at a granular level down to individual genes and even changes within those genes. Using microarrays, like the Affymetrix GeneChip technology, researchers can compare entire genomes of humans, various primates and other animals, placing them in consecutive evolutionary order.
They can also use microarrays, which are like computer chips that contain genetic information, to examine what genes are expressed or not expressed in a given organ, the brain, for example.
An increasingly popular microarray technology is one invented by Joseph DeRisi and Pat Brown at Stanford, for which DeRisi recently won a MacArthur prize.
The authors suggest that the DeRisi technology may actually be better than the Affymetrix technology (which is about 10 times more expensive) for studying large numbers of genes.
Geschwind and his colleagues found that while the studies they compiled may have shown disparate conclusions individually, taken together the research came to some similar conclusions.
For example, the scientists were excited to find that the gene regulation was different from chimps almost exclusively in the brain, and not in other organs like the liver or heart. That proves that the genetic differences are specific to the brain, and likely are associated with our higher cognitive function, Geschwind said.
"And that's allowed us and other people to show that there's been a lot of selective pressure and accelerated evolution in the brain," he added.
The researchers also found that the genes were more often turned on, or "upregulated" in the human brain as opposed to the chimp brain. Although they don't know why this is, the scientists believe this finding might be a key to new insights.
They do have one theory Geschwind said: "It may be that the human brain is a like a V-8 or a V-12 and the chimp brain is a V-4."
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