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This is a work published in the journal Cell Metab by authors from East China University of Science and Technology at Shanghai. The work is quite original in that it describes a novel NADH-measuring technique claimed to be advantageous mainly in two aspects: 1 superior sensitivity and specificity, 2 capable of measuring changes in cellular total NADH or (intracellular) compartmental NADH. Personally, I'm not that much interested in the technique per se. Rather, what really interests me is the finding that NADH response to perturbation in cytosol is temporally separated from that in mitochondria. And the view that cytosolic NADH is sensitive to environmental changes, while mitochondria have a strong tendency to maintain physiological NADH homeostasis. These provide significant clues for my own work.