caused by antibiotics with yet another antibiotic?

Does "caused by antibiotics with yet another antibiotic" mean:

caused by a variety of antibiotics?

Quote:

Does "caused by antibiotics with yet another antibiotic" mean:

caused by a variety of antibiotics?

It's hard to say for sure, Ori. I suppose that a disease can be treated by a number of different antibiotics.

"We are treating a disease caused by antibiotics with yet another antibiotic."

HA! I just looked at the link and saw that it's about C-diff!

No.

Split the sentence into its constituent parts, and you'll understand it better.

Quote:

"We are treating a disease caused by antibiotics with yet another antibiotic."

We
are treating
a disease caused by antibiotics
with
yet another antibiotic

because the first one had "caused" the C-Diff to proliferate by wiping out all of the normal gut bugs that usually keep the nasty ones in check.

Quote:

because the first one had "caused" the C-Diff to proliferate by wiping out all of the normal gut bugs that usually keep the nasty ones in check.

How does that happen, JPB? Did they keep giving massive doses that killed the good gut bugs? Or has that always been the case that good gut bugs have also been killed along with the infection being treated?

Clostridium difficile causes diarrhea and colitis by releasing two potent toxins into the gut lumen that bind to intestinal epithelial cells, initiating an inflammatory response. These toxins are released only when the Clostridium difficile bacteria are multiplying. When antibiotics are used to treat another infection, it changes the bacterial landscape in the gut and, in the process, may kill bacteria that under normal conditions would compete with Clostridium difficile for energy. Scientists believe this may be what provides the opportunity for Clostridium difficile to grow and release its toxins.

I think it's more of an issue with which antibiotic is chosen first. In my daughter's case she was over-prescribed a "big gun" broad spectrum antibiotic for a routine UTI. It wiped out everything except the C-diff which then proliferated and caused a secondary infection (this time in her colon). She never should have been prescribed the Cipero -- it's not even indicated as first line treatment of UTIs, only "complicated UTIs" and hers certainly wasn't complicated. Of course, we only learned all this while sitting in the ER with her so she could get some IV solutions pumped in to counteract the dehydration associated with the C-diff infection.

The whole thing completely affected the normal workings of her gut. She was then prescribed one of the two antibiotics mentioned in the article along with a probiotic to try to reinstate normal flora. That was in early July. I don't think she's going to be one of the 20% that has to deal with chronic reinfection (a lifelong problem for many C-diff sufferers, particularly the elderly) because she is young and generally healthy, but she's still not back to her old self. She's dropped about 15lbs (10 of which she'd gained the year before as a college freshman) but she was already thin. She's 5'11" tall, weighs 137 lbs, and has no appetite whatsoever.