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Wed 13 Jul, 2011 05:31 pm
this function = that shapes chromosomes so they'll direct the cell to remain a stem cell?
Context:
The discovery of the microRNAs' ability to switch the cells came to light when Andrew Yoo, PhD, then a postdoctoral researcher in Crabtree's lab (now on the faculty of Washington University in St. Louis), was trying to better understand what makes neural stem cells move on to become mature neurons. He found that two microRNAs, miR-9/9* and miR-124, trigger it by controlling a molecular machine (called the BAF chromatin remodeling complex) that shapes chromosomes so they'll direct the cell to remain a stem cell.
"When the microRNAs bind to one subunit of this 13-membered complex they turn this function off, and the cells begin to grow up and connect to one another -- that is, they become mature, functioning neurons," said Crabtree. After they published this in Nature in 2009, Yoo went on to try to understand how the two microRNAs functioned. One way he did this was to watch what happened when he introduced them into cells that normally lacked them.
@oristarA,
Read this sentence again:
He found that two microRNAs, miR-9/9* and miR-124, trigger it by controlling a molecular machine (called the BAF chromatin remodeling complex) that shapes chromosomes so they'll direct the cell to remain a stem cell.
You've chopped up the end of the sentence you are asking about. It reads " . . .
turns this function
off." So the BAF chomatin remodeling complex is turned off--this function means the the action whereby the BAF chromatin remodeling complex is turned off.
@Setanta,
Setanta wrote:
Read this sentence again: He found that two microRNAs, miR-9/9* and miR-124, trigger it by controlling a molecular machine (called the BAF chromatin remodeling complex) that shapes chromosomes so they'll direct the cell to remain a stem cell.
You've chopped up the end of the sentence you are asking about. It reads " . . . turns this function off." So the BAF chomatin remodeling complex is turned off--this function means the the action whereby the BAF chromatin remodeling complex is turned off.
Could not understand you well, Set.
Supposed "the BAF chomatin remodeling complex" is A. So "turns the function off" means "turns A's function off?"
. . . the BAF chromatin remodeling complex . . . that shapes chromosomes so they'll direct the cell to remain a stem cell=this function.
two microRNAs, miR-9/9* and miR-124=turn off this function.
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