@Setanta,
Im back at your question re: gravity anomalies, the health effects that the Mir guys and the ISS crews are experiencing is caused mostly by weightlessness . . I knnew of bone density issues and some myopathies on organs but didnt know of anything that was lasting. (Even the bone density issues were reversed after a year back on earth).
Now, however, long term TDY's on , say, the Moon, may not be as reversable since the forces that apply will be acting on a single plane rather than triaxially as in outer space. SO, will anything change over generations? I have no idea because we would be trying to set up artificial environments and whenever we go outside wed have to wear our environment as a space suit.
I guess cardiomyopathy is a serious consequence but even this can be handled by drugs. I think space can mostly be handled like a chronic condition.
I found that a two foot layer of a specific density of hydrogen gas or water can act as a good cosmic radiation buffer. In one area a water shell can act as a reservoir or trombe shell (passive solar heat) or the hydrogen gas shell can act as a balloon . SO, in my minds art. I see the town on the moon being a series of dwellings that look like various sized igloos.