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and most importantly = and most importantly bind to the CD19 receptor?

 
 
Reply Sat 19 Feb, 2011 05:05 am
Context:
Lymphocytes are a type of white blood cell involved in immune function and are categorized as either B-cells or T-cells. This newly discovered element, CD19-L, is expressed on the surface of T-lymphocytes and allows them to selectively bind to the CD19 receptor on the surface of B-lineage leukemia cells, and most importantly on leukemic stem cells responsible for the survival and expansion of the leukemia cell population. Once the CD19-L binds to leukemia cells, cell death occurs. Although CD19 is abundantly expressed on leukemia cells from B-lineage ALL patients, it is absent on red cells, T-cells, and normal bone marrow stem cells, making it specific, and therefore, a good therapeutic target.

More:

http://www.sciencedaily.com/releases/2011/02/110218152821.htm
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Type: Question • Score: 0 • Views: 410 • Replies: 2
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McTag
 
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Reply Sat 19 Feb, 2011 10:10 am
@oristarA,

No.

The CD19-L is on the surface of T-lymphocites.
This allows them to bind to the receptor on the surface of leukaemia cells,
and principally, on to those cells responsible for the....survival of the cancer cells.
This brings about the death of the cells.
Hooray.
oristarA
 
  1  
Reply Sun 20 Feb, 2011 07:49 am
@McTag,
Thanks
0 Replies
 
 

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