I honestly don't spend a lot of time thinking about government paternalism. Marijuana is against the law, so I don't touch the stuff, but it wouldn't bother me if they legalised it. The point
wayne made about vested interests acting as a domineering older sister and trying to "influence Nanny" is the only reason I would worry about this issue--that and all the tedious red tape.
AIDS, the situation in the atmosphere, the situation in the Middle East, nuclear proliferation, overpopulation, species extinction; those are the issues I care about.