t the drop in B cells after a BAFF inhibitor in humans disease ?

t the drop in B cells after a BAFF inhibitor in humans disease = t the drop in the number of B cells after using a BAFF inhibitor in humans disease ?


Context:

BAFF’s cousin APRIL is also a ligand for TNF, but its biology is not well understood and at present appropriate reagents or therapeutic modulators for it do not exist. Clinical development of BAFF inhibitors to date has revealed that dependence on BAFF for B-cell survival is not the same in mice and human, in that the drop in B cells after a BAFF inhibitor in humans disease has been lower than that predicted from rodent models [26]. While elevated levels of BAFF increase production of autoreactive cells, the elevation itself may be the result of infection, hormones or other epigenetic factors.