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Fri 26 Nov, 2010 11:20 pm
Does "Mel Berger, CSL Behring and Case Western Reserve University, Cleveland, OH" means "Dr. Mel Berger who works both in CSL Behring and Case Western Reserve University, Cleveland, OH"?
Context:
Autoimmunity in antibody deficiency syndromes actually features a broader B cell repertoire and lymphoid hyperplasia, implicating the germinal center as a critical location for in the development of autoimmunity (Mel Berger, CSL Behring and Case Western Reserve University, Cleveland, OH). While in general a diverse repertoire is desired, it has to be the right kind of diversity. Since differentiated plasma cells do not express CD20 and would not be depleted by it, it is now clear that autoantibodies might also be made by immature or mature B cells [24]. Therefore, genetically based defects in the transition from B cell to plasma cell might increase the potential for autoimmunity.