T cell lymphopenia = which?

"Which" means that T-cell lymphopenia results in the proliferation which is required to maintain T-cell homeostasis. The writing in this stuff really sucks.

You're right, Ori.

Defects in T cell homeostatic mechanisms can result in T cell lymphopenia.

It [T cell lymphopenia] results in proliferation in order to maintain T cell homeostasis, and this may expand the pool of autoreactive T cells that promote autoimmunity.

Thank you both.

What proliferation then? Lymphocyte proliferation ?

Plus, antoimmunity here refers to self-immune? Not antoimmunity disease?

Specifically, T cell proliferation.

T cells are produced in the thymus. The self-reactive T cells that are occasionally produced are usually cleared before being released out of the thymus. The few that make it out are controlled by the peripheral tolerance system. In the case of leukopenia, lymphocycte counts are very low and the thymus is pushed into overdrive. Vast numbers of leukocytes are produced and released. The self-regulating clearance systems get bogged down and can't keep up with production, meaning that more self-reacting cells are released. These self-reacting T cells promote autoimmune diseases.

Thank you.

Specifically, did you mean "autoimmunity here means autoimmunity diseases"?

yes

No, 'which' does not mean that. 'which' is a relative pronoun that fills in for "T-cell lymphopenia".

Aren't you the limp brain, Set, that has been complaining about the grammar in these posts of Oristar's?

To promote diseases is derogtory. I've alwasys thought "promote" is a commendatory term.