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Thu 25 Nov, 2010 08:54 pm
attributed to = because of?
If so, I don't think " attributed to a loss of function mutation of critical transcription factors" holds water.
Should it be " attributed to a loss of function caused by mutation of critical transcription factors?"
Context:
APECED, IPEX and Omenn syndrome all associate with aberrant thymic function with failure of production and function of the regulatory T cell elements, attributed to a loss of function mutation of critical transcription factors, AIRE in APECED and FOXP3 in IPEX.
@oristarA,
Whoever wrote that would never have gotten past tenth grade English where I went to school.
Logic will only hold you back my friend
@oristarA,
I agree, the sentence sucks. I'd say that your solution is probably correct, but couldn't state that to a certainty without more context. However, given how poorly all of these immunology texts are written, even that might not help.
By the way, in this context, "attributed to" means that it is supposed that the effect is because of the cause alleged.
@oristarA,
Quote:APECED, IPEX and Omenn syndrome all associate with aberrant thymic function with failure of production and function of the regulatory T cell elements, attributed to a loss of function mutation of critical transcription factors, AIRE in APECED and FOXP3 in IPEX.
One possible interpretation of the sentence might be:
Quote:APECED, IPEX and Omenn syndrome are all associated with aberrant thymic function and with failure of production and function of the regulatory T cell elements; this is attributed to a loss of function caused by mutation of critical transcription factors, AIRE in APECED and FOXP3 in IPEX.
That's decent English but you'd have to talk to the quasi-literate scientist who wrote the original sentence to determine if that or something else is what he actually meant.
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