Reply
Thu 25 Nov, 2010 07:27 pm
Context:
IPEX is due to inheritance of a mutationally disrupted X-linked gene for the transcription factor FOXP3 [11]. FOXP3 is required for the function of natural (thymus-derived) regulatory T cells (nTregs) (Troy Togerson, University of Washington, Seattle, WA) that develop in the thymus from whence they migrate to the periphery to maintain peripheral tolerance, so protecting the host from effects of autoaggressive or exuberantly reactive T lymphocytes [12]. T
@oristarA,
Quote:mutationally disrupted
Mutation is a regular aspect of evolution. Mutation occurs randomly either from error, environment, chemicals, diet, lifestyle, etc. It means the gene in the X chromosome has been affected by mutation.
@talk72000,
Oops! I've misread the word "mutationally" as another word.
But yes, thank you.
Stumble It!
Tweet This
Bookmark on Delicious
Share on Facebook
Share on MySpace