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Mon 15 Nov, 2010 12:49 am
Context:
Autoimmunity in antibody deficiency syndromes actually features a broader B cell repertoire and lymphoid hyperplasia, implicating the germinal center as a critical location for in the development of autoimmunity (Mel Berger, CSL Behring and Case Western Reserve University, Cleveland, OH). While in general a diverse repertoire is desired, it has to be the right kind of diversity. Since differentiated plasma cells do not express CD20 and would not be depleted by it, it is now clear that autoantibodies might also be made by immature or mature B cells [24]. Therefore, genetically based defects in the transition from B cell to plasma cell might increase the potential for autoimmunity.
@McTag,
Thanks.
I wonder whether others will agree this.
@oristarA,
Well who cares?
If anyone disagrees with me, they're wrong. Ipso facto.
@McTag,
Thank you McTag.
Let's boil it down to the technique term of immunology.
@McTag,
McTag wrote:
behaviour.
range of behaviours.
Or, effect/ effects
Almost! Every B cell has receptors that are unique to a specific antigen. The B cell repertoire refers to the involvement of the entire range of potential, available, and utilized B cells. I'll link an article that's specific to B cell repertoire, but it may be more than you're looking for. In the context of your quote, "Autoimmunity in antibody deficiency syndromes actually features a broader B cell repertoire", I can only guess what the author is referring to, but it appears to be an assessment against a theory of fewer specific B cell receptor involvement.
Quote:In this report we will review recent developments that
focus on the formation of the murine B cell repertoire.
This area has captured the interest of many active investigators,
and new information is being rapidly added to
the literature. Because of this, our review will be incomplete
and limited to those points we find most interesting.
Following Jerne’s (1) lead, most workers in this field
find it helpful to distinguish among three concepts of
repertoire: potential, available, and utilized (2).
Full pdf
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