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Sun 14 Nov, 2010 12:02 am
B cell tolerance is identifiable and is seen as"central" when B cell tolerance has been set up in the bone marrow?
Context:
6.3. B-cell tolerance
The increased recognition of the role of B cells in autoimmunity
has led to renewed interest in the checkpoints that govern B cell
tolerance, identifiable as ‘central’ when established in the bone
marrow and ‘peripheral’ after B cells have exited to the periphery.
Genetically determined defects that have an impact in either site
can result in malfunctioning B cells and/or the accumulation of
autoreactive B cells in the blood (Eric Meffre Yale University, New
Haven, CT). Failure at these major B cell tolerance checkpoints is
common among a range of autoimmune diseases, and suggest that
anti-B cell-based therapies could potentially prevent or delay many
autoimmune diseases, additional to their use in the main indica-
tion, rheumatoid arthritis.
@oristarA,
Your question is not very clearly put.
However your dictionary will help with the meaning of "to identify"
The cells can be described as "central" or "peripheral" according to where they are found.
the checkpoints [that are] identifiable as ‘central’ when established in the bone
marrow and ‘peripheral’ after B cells have exited to the periphery.
@contrex,
the checkpoints [that are] identifiable as ‘
central checkpoint’ when established in the bone marrow and ‘
peripheral checkpoint’ after B cells have exited to the periphery?
looks that way; you're the medical person, not me.
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