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To? What to?

 
 
Reply Sat 13 Nov, 2010 07:05 pm


Context:

Phenotypes in complement-deficiency states include particu-
larly SLE or other multisystem/vasculitic autoimmune diseases,
membranous-proliferative glomerulonephritis type II (MPGM II),
and defective host defense against bacterial (often neisserial or
pyogenic) infections and to a lesser extent virus infections [33].
Mechanisms for disease in genetically determined C’ deficiencies
include defective clearance of immune complexes or apoptotic
cells, and defective antibody-dependent anti-microbial activities.
As well as occurrence of multisystem autoimmunity, two particular
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JPB
 
  1  
Reply Sat 13 Nov, 2010 08:22 pm
@oristarA,
"to a lesser extent" in this context means less commonly seen than those in the previous list. It contrasts with "particularly" which I would equate to especially.
oristarA
 
  1  
Reply Sat 13 Nov, 2010 11:36 pm
@JPB,
Thanks.

against bacterial (often neisserial or
pyogenic) infections and against particulayly a lesser extent virus infections?
JPB
 
  1  
Reply Sun 14 Nov, 2010 11:07 am
@oristarA,
Quote:
Phenotypes in complement-deficiency states include particularly SLE or other multisystem/vasculitic autoimmune diseases, membranous-proliferative glomerulonephritis type II (MPGM II), and defective host defense against bacterial (often neisserial or pyogenic) infections and to a lesser extent virus infections [33].


hmmmm... now that I'm rereading this, I think "to a lesser extent" is contrasting viral infections to bacterial infections rather than the entire list preceding it. The grammar gurus can weigh in, but I think the format

"...include particularly w, x, and y and to a lesser extent z"

is contrasting z and y, not z to all of w, x, and y.
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