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Fri 12 Nov, 2010 07:43 am
Context:
Inherited complement deficiencies predispose to autoimmune rheumatic diseases and angioedema as well to susceptibility to infections (Jerry Winkelstein, Johns Hopkins University, Baltimore, MD) [33]. Since there is linkage disequilibrium of complement genes with MHC genes, there can be coinheritance of genes for immunodeficiency and for autoimmune disease. Inheritance of C0 deficiencies is autosomal recessive, and usually heterozygous. The gene variants can involve any of the components of the classical pathway, C1q to C9.
It means all the components in that pathway.
@Setanta,
Thanks.
But it is better to be more concrete.
Waiting for JPB.
c1q (to) - c9 has no meaning to those of use that have no training in the field of genetics other than, as indicated, that this is the name of the pathway refered to. Nor does componants, other than the word componants describes all or some of the parts of the whole (pathway).
@oristarA,
oristarA wrote:Context:
Inherited complement deficiencies predispose to autoimmune rheumatic diseases and angioedema as well to susceptibility to infections (Jerry Winkelstein, Johns Hopkins University, Baltimore, MD) [33]. Since there is linkage disequilibrium of complement genes with MHC genes, there can be coinheritance of genes for immunodeficiency and for autoimmune disease. Inheritance of C0 deficiencies is autosomal recessive, and usually heterozygous. The gene variants can involve any of the components of the classical pathway, C1q to C9.
Yes, as Set indicated, the C1q - C9 complement components refers to the entire classical pathway. This differs from the alternative complement pathway as indicated in the schema below:
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