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X-shapes = conformation?

 
 
Reply Sun 31 Oct, 2010 08:09 pm

1) X-shapes = conformation = these large, non-random structures?

2) spend the time clumped = spend the time clumping (the conformation together)?

Context:

"People are familiar with the X-shapes our chromosomes form during cell division, but what they may not realize is that DNA only spends a relatively small amount of time in that conformation," said Ken-ichi Noma, Ph.D., an assistant professor in Wistar's Gene Expression and Regulation program and senior author of the study. "Chromosomes spend the majority of their time clumped together in these large, non-random structures, and I believe these shapes reflect various nuclear processes such as transcription."

More:

http://www.sciencedaily.com/releases/2010/10/101029122215.htm
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JPB
 
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Reply Sun 31 Oct, 2010 08:44 pm
@oristarA,
Just before a chromosome replicates (makes a new copy of itself) it takes on the shape=conformation of an X

http://www.biologylessons.sdsu.edu/classes/lab8/unreplicated.gif

But most of the time it isn't in an X-shape, it's clumped up with a bunch of other chromosomes in "particular patterns" = large, non-random structures. These patterns represent various nuclear processes...

http://www.biologylessons.sdsu.edu/classes/lab8/interphase.gif
JPB
 
  1  
Reply Sun 31 Oct, 2010 08:51 pm
@oristarA,
http://upload.wikimedia.org/wikipedia/commons/d/db/Prophase.jpghttp://upload.wikimedia.org/wikipedia/commons/9/9e/Prometaphase_1.jpghttp://upload.wikimedia.org/wikipedia/commons/1/19/Metaphase.jpghttp://upload.wikimedia.org/wikipedia/commons/f/f5/Anaphase.jpghttp://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Telophase.jpg/175px-Telophase.jpgSource

The chromosomes only take on the X-shape or conformation for a short period of time as part of cell division. Most of the time they are in clumps as in the first picture.
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oristarA
 
  1  
Reply Sun 31 Oct, 2010 09:25 pm
@JPB,


Thank you very much JPB.

Thus, "particular patterns" = large, non-random structures = a tangle clump of chromosomes?

Context:

A given cell's DNA spends most of its active lifetime in a tangled clump of chromosomes, which positions groups of related genes near to each other and exposes them to the cell's gene-controlling machinery. This structure, the researchers say, is not merely the shape of the genome, but also a key to how it works.

More:

http://www.sciencedaily.com/releases/2010/10/101029122215.htm
JPB
 
  1  
Reply Sun 31 Oct, 2010 10:03 pm
@oristarA,
Yes. The chromosomes are in a large tangled clump but the layout of the clump isn't random.
oristarA
 
  1  
Reply Sun 31 Oct, 2010 10:21 pm
@JPB,
Thanks.
0 Replies
 
 

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