Reply
Tue 21 Sep, 2010 07:02 am
Context:
"The molecular mechanisms that allow Mycobacterium tuberculosis to switch into this slow-growing, persistent state have been associated with genes that are activated when the microorganism is under stress," said Igoshin, senior author of the study and an assistant professor in bioengineering at Rice.
Tiwari, lead author of the study and a graduate student in Igoshin's lab, said, "We examined a stress-response network of genes that are found in both the TB bacterium and other closely related mycobacteria. We analyzed the role of multiple feedback loops in this network, and were eventually able to identify an ultrasensitive mechanism that works in combination with the feedback loops to form a switch. This switch can possibly activate transition to the persistent state."
No, it was mainly Tiwari's work, probably his dissertation work for a Ph.D., he's a graduate student or maybe post-doc.. He did the work under the general direction of Igoshin, who is a faculty member and the head of the lab. Igoshin probably gave him a good deal of suggestions, might have suggested the project to Tiwari as something that would be a good topic to research. Igoshin is the older, more experienced person, who supervised, but didn't do most of the actual work. Tiwari;s name would appear first (the "lead") in the list of names of people who authored the paper.
Stumble It!
Tweet This
Bookmark on Delicious
Share on Facebook
Share on MySpace