@Solmeci,
I think it depends on your relationship with your wife's best friend and her boyfriend. If these are two people you are friends with and care about generally, then it would be a little insensitive if you didn't give a whip about their fighting. But if you really don't have much of a relationship with them, then why should you care if the spend all their lives fighting and arguing (unless punches are being thrown, in which case showing some concern and getting involved may be warranted.)
But as was said previously, if it keeps your wife happy, then by all means show a bit of concern. You don't want to start arguing all the time with her over your lack of concern for her friend's arguing all the time. lol