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Tue 20 Jul, 2010 10:01 pm
"modified from Savidge TC et al"?
The picture was made by Savidge TC and others, and Lee and Mazmanian modified the picture, and then Lee and Mazmanian have had the credit of the picture?
Context:
In the absence of bacteria in the intestines, pro-inflammatory Th17 cells do not develop in either the gut or the central nervous system; and animals do not develop disease (top panel). When animals are colonized with symbiotic segmented filamentous bacteria, Th17 cell differentiation is induced in the gut. Th17 cells promote experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis. In this way, non-pathogenic bacteria of the microbiota promote disease by shaping the immune response in both the gut and the brain (top panel). (Credit: Lee, Mazmanian/Caltech; modified from Savidge TC et al. Laboratory Investigation 2007)