@Dave Allen,
Dave Allen;91184 wrote:I find Gould rather dry myself, though I did like Bully for Brontosaurus.
Eight Little Piggies was great.
By the way, for those who keep insisting that major phenotypic changes (like development of whole organs) can't be accounted for by small genetic regulatory changes (in combination), I need only refer you to the phenomenal study done in
Science a few years ago looking at the genetic diversity of domestic dogs (after the dog genome was sequenced).
All dogs are in the same species -- everything from greyhounds to pit bulls to newfoundlands to chihuahuas. They're all close relatives of wild wolves.
The differences between these dogs is clearly heritable, right? I mean if you put two chihuahuas together you get a chihuahua puppy and not a schnauzer.
All of the genetic variability in dogs, which must account for the size, shape, and behavioral signatures of different breeds, boils down to just a few regulatory genes -- all these different dogs are extremely closely related genetically. Some of them are the same gene but they have repeated motifs. It's amazing how little
sequence variability results in so much
morphologic variability.
Extrapolate this to organ systems. In embryogenesis all vertebrates have branchial arches. In fish these develop into gills. In mammals they develop into ears, the eustacian tubes, the thyroid, and other upper airway structures. In other words, the embryogenesis is shared for a major part of fetal development -- but with different regulatory signals and proximity to different structures (i.e. paracrine influence), the ultimate developmental paths diverge. In this way enormous changes in structure and function are produced by a relatively small amount of genetic variability.
Combinatorial probability is extremely important. If you take a 10 nucleotide segment of DNA, and each nucleotide is going to be one of four options (ATCG), then variability in just 3 of these 10 loci will give you 81 possible combinations. Now take a second and a third segment with the same parameters a measly 10 nucleotides that can each vary at 3 loci (and have 81 possibilities each) -- that makes more than 531,000 possible combinations. In other words, a tremendous amount of genetic diversity can be generated with very small changes in genetic sequence.