This will be the first time that The Netherlands and Spain have ever met in a major tournament (World Cup or European Championship).
I can't see Spain dominating the midfield as they did against the Germans. Van Bommel and de Jong will be kicking lumps out of Iniesta, Xavi et al. Spain may be forced to alter their tactics and get the ball out wide rather than trying to pass their way through the middle.
Expect a few goals in the 3rd place play-off - Klose at least has something to play for (all-time goalscoring record).