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full-strength strain = full-strength HIV virus strain ?

 
 
Reply Fri 19 Feb, 2010 09:47 am

Context:

VIRxSYS is not the first company to successfully test SIV-based vaccines in monkeys. A team led by David Evans of Harvard Medical School in Southborough, Massachusetts, reported successfully protecting monkeys a year ago with a similar "single-cycle" vaccine, this time containing all but one of the SIV genes, but he had no intention of transferring the work to people.

There is still the possibility, however, that in people that already have HIV, the vaccine version of the virus could recombine with the incumbent full-strength strain, and evolve into an even more potent adversary.

Evans thinks VIRxSYS has made this less likely by limiting the vaccine virus to a single cycle of infection. "That certainly makes it safer than a replication-competent live attenuated virus," he says.

More context, click:
http://www.newscientist.com/article/dn18551-fight-hiv-with-hiv-safe-virus-proposed-as-vaccine.html
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engineer
 
  1  
Reply Fri 19 Feb, 2010 09:50 am
@oristarA,
Many vaccines are made from weakened viruses that the body can beat, at the same time providing immunity against the "full strength" version. Here, full strenght means a virus that has not been artificially weakened.
oristarA
 
  1  
Reply Fri 19 Feb, 2010 09:59 am
@engineer,
Thanks.

Who would like to tell me whether the strain in this context particularly refers to full-strength HIV virus strain?
engineer
 
  1  
Reply Fri 19 Feb, 2010 10:14 am
@oristarA,
People who already have HIV have the "full strength" version. The article is saying that if you give the weakened virus to those who are already infected (have the full strength version) it will hurt them since it will reinforce the virus already there.
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